Opportunity Information: Apply for PAR 18 600

The Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed), listed as PAR-18-600, is a National Institutes of Health (NIH) funding opportunity under the U.S. Department of Health and Human Services. It is designed to help research institutions strengthen their scientific capabilities by funding the purchase or upgrade of one major, commercially available piece of specialized research equipment (or an integrated instrument system). The basic idea is to support shared resources: instead of funding equipment for a single lab, NIH expects the instrument to be used by a group of NIH-supported investigators who will rely on it for ongoing, high-impact biomedical research. As the title indicates, applications proposing clinical trials are not allowed under this announcement.

This program focuses specifically on expensive, advanced instruments that are critical for modern biomedical and health-related research and that typically exceed what an individual investigator could easily obtain through standard research project budgets. The solicitation highlights that awards must be used for a single instrument or system, emphasizing shared access and broad utility rather than multiple smaller purchases. The range of eligible equipment is intentionally broad, and examples include X-ray diffractometers, mass spectrometers, nuclear magnetic resonance (NMR) spectrometers, DNA and protein sequencers, biosensors, electron and light microscopes, cell sorters, and biomedical imaging systems. In practice, this scope covers many of the core technologies used in structural biology, proteomics, genomics, cell biology, materials and biomaterials research, and translational biomedical engineering, as long as the instrument is commercially available and will be operated as a shared resource.

From a funding standpoint, the SIG Program sets a minimum award size of $50,000 and an award ceiling of $600,000. While the opportunity notes that there is no maximum instrument price requirement, NIH will not provide more than $600,000 through this mechanism, meaning institutions may need to cover any costs beyond that cap through cost-sharing, institutional funds, or other sources if they pursue equipment priced above the ceiling. The opportunity anticipates making about 75 awards, which signals a competitive national program but also one with a meaningful number of annual awards relative to many specialized equipment competitions.

Eligibility is oriented toward U.S. research-performing organizations that can house and manage shared instrumentation. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities) that meet NIH requirements. The listing also includes an “Others” category with additional eligibility details referenced in the full announcement, which typically clarifies special cases or organizational types that may apply. The opportunity is categorized as discretionary funding and uses the grant funding instrument type, with health as the primary activity category. The CFDA (now often referred to as Assistance Listing) numbers associated with the opportunity are 93.351 and 93.859, reflecting NIH program authorities tied to research infrastructure and relevant health research funding areas.

Overall, the SIG Program is best understood as an infrastructure investment mechanism that helps institutions keep pace with rapidly evolving research technologies by placing major instruments into shared facilities or core laboratories. A strong application generally aligns the requested instrument with clear, ongoing NIH-supported research needs across multiple investigators, demonstrates that the instrument will be heavily used, and shows that the institution can operate, maintain, schedule, and provide access to the equipment in a way that maximizes scientific benefit. The program’s emphasis on a group of NIH-supported users and on shared use underscores its central purpose: expanding access to high-end instrumentation that can accelerate discovery across many projects rather than only one.

  • The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.351, 93.859.
  • This funding opportunity was created on Jan 29, 2018.
  • Applicants must submit their applications by May 31, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $600,000.00 in funding.
  • The number of recipients for this funding is limited to 75 candidate(s).
  • Eligible applicants include: Public and State controlled institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for PAR 18 600

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