Administrative Supplements to Support Cancer Disparity Collaborative Research (Clinical Trial Optional) | PAR 22 114

Opportunity Information: Apply for PAR 22 114

Administrative Supplements to Support Cancer Disparity Collaborative Research (Clinical Trial Optional) (PAR-22-114) is a trans-NCI funding opportunity from the National Institutes of Health that provides administrative supplements to existing NCI-supported grants so those projects can add or strengthen a cancer health disparities component through collaboration. The central idea is to bring together investigators who do not typically focus on cancer disparities with researchers who do, and to use that partnership to speed up and broaden multidisciplinary work aimed at understanding and reducing unequal cancer outcomes across populations. Because this is an administrative supplement, the proposed work must remain within the scientific scope of the active parent award, but it is expected to expand the parent project’s aims by integrating a clear disparities-focused question, approach, cohort, or analytic plan.

The FOA supports a wide range of cancer disparities research areas and methods. Projects may be basic, translational, behavioral, observational, interventional, environmental, or population-based, and clinical trials are optional. What ties eligible projects together is their focus on addressing adverse differences in cancer incidence, prevalence, mortality, survivorship, overall burden, and/or response to treatment, particularly among racial and ethnic minority groups and other underserved populations. The announcement emphasizes that proposed collaborations should be driven by research objectives that genuinely require complementary expertise, technical capabilities, and resources across partners, rather than simply adding a small ancillary aim. It also notes the possible inclusion of international comparator cohorts, when appropriate and consistent with the parent grant, as a way to strengthen inference about drivers of disparities.

This opportunity is a coordinated, institute-wide NCI effort supported by multiple NCI divisions and centers: the Division of Cancer Biology (DCB), Division of Cancer Treatment and Diagnosis (DCTD), Division of Cancer Prevention (DCP), Division of Cancer Control and Population Sciences (DCCPS), the Center to Reduce Cancer Health Disparities (CRCHD), and the Center for Global Health. That broad sponsorship signals that the program is meant to cut across the cancer research continuum, from mechanisms and etiology to prevention, treatment, survivorship, and implementation in real-world settings, with a consistent emphasis on equity and measurable disparities.

Eligibility is broad and includes many organization types that commonly hold NIH awards, such as public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and various government entities (state, county, city/township, special district), as well as independent school districts and public housing/Indian housing authorities. The FOA also highlights categories of applicants that are especially relevant to disparities and community-engaged work, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations and regional organizations. Federally recognized tribal governments are listed as eligible, and the FOA also references Indian/Native American tribal governments other than federally recognized in the highlighted categories.

The geographic and foreign involvement rules are specific. Non-domestic (non-U.S.) entities and non-domestic (non-U.S.) components of U.S. organizations are not eligible to apply for the supplement. At the same time, foreign components, as defined by NIH policy, are allowed, which aligns with the FOA’s mention of potentially using international comparator cohorts while keeping the applicant organization itself U.S.-based and the overall arrangement compliant with NIH rules.

In practical terms, this FOA is designed for an existing NCI awardee who can legitimately extend their ongoing project to include a cancer disparities dimension by forming a collaboration that adds new perspectives, populations, measures, methods, or resources. The goal is not just to document unequal outcomes, but to strengthen the evidence base in ways that can clarify drivers of disparities and support better prevention, diagnosis, treatment, and survivorship outcomes for underserved groups, all while building durable cross-disciplinary partnerships.

Key administrative details from the listing include: the funding instrument is a grant administrative supplement under a discretionary opportunity category; the activity category is Education and Health; CFDA numbers include 93.393 through 93.399; and the opportunity close date is listed as 2025-01-23. The listing does not specify an award ceiling or expected number of awards in the provided fields, which typically means applicants should refer to the full FOA and parent award IC guidance for budget and supplement duration expectations.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Administrative Supplements to Support Cancer Disparity Collaborative Research (Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.397, 93.398, 93.399.
• This funding opportunity was created on 2022-02-25.
• Applicants must submit their applications by 2025-01-23. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 22 114

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