Opportunity Information: Apply for PAR 20 077
The National Cancer Institute (NCI), part of the National Institutes of Health (NIH), is soliciting investigator-initiated applications under the Program Project Grant mechanism (P01) through Funding Opportunity Announcement PAR-20-077, titled "National Cancer Institute Program Project Applications (P01 Clinical Trial Optional)." This opportunity is meant to support large, coordinated research programs that tackle important cancer-related questions through multiple, interlinked projects rather than a single stand-alone study. The FOA is broad by design and allows applicants to propose research across essentially the full spectrum of cancer science, including (but not limited to) cancer biology, prevention, diagnosis, treatment, and cancer control. NCI indicates that basic, translational, clinical, and population-based approaches are all responsive, and the "clinical trial optional" designation means the overall application may include clinical trial work when appropriate, but clinical trials are not required.
A central feature of this program is the expectation of an integrated, theme-driven structure. Each P01 application must include at least three distinct research projects, plus an Administrative Core. The required projects cannot be a loose collection of unrelated aims; they must be connected by a shared central theme, focus, and/or overarching objective, and they should be designed to generate added value through coordination, shared resources, complementary expertise, and scientific synergy. In practical terms, reviewers will expect the projects to reinforce one another, create efficiencies, and produce outcomes that would be difficult to achieve if the projects were funded separately. The Administrative Core is required because NCI expects substantial program-level coordination, governance, communication, planning, and management across the projects, including oversight of timelines, milestones, reporting, meetings, and integration activities.
Eligibility is intentionally expansive and includes a wide range of domestic organizations and government entities. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); and Native American tribal organizations (other than federally recognized tribal governments). The FOA also allows public housing authorities/Indian housing authorities, for-profit organizations (other than small businesses), small businesses, and nonprofit organizations both with and without 501(c)(3) status (so long as they are not institutions of higher education when specified). NCI also highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), as well as faith-based or community-based organizations, eligible federal government agencies, regional organizations, and U.S. territories or possessions. The FOA draws a clear boundary on foreign involvement: non-domestic (non-U.S.) entities and non-domestic (non-U.S.) components of U.S. organizations are not eligible to apply. However, foreign components, as defined under the NIH Grants Policy Statement, are allowed, meaning a U.S.-based applicant may include certain types of international collaboration elements if they meet NIH policy requirements.
From an administrative cataloging standpoint, the opportunity is categorized as discretionary funding and uses the grant funding instrument, with activity aligned to Education and Health. It is associated with CFDA numbers 93.393, 93.394, 93.395, 93.396, and 93.399, which reflect NIH/NCI program areas tied to cancer research and training infrastructure. The FOA record lists an original closing date of 2023-05-07 and a creation date of 2020-01-27; applicants should treat those dates as specific to this posting and verify current submission windows and any reissues or updates directly in NIH systems before planning a submission. Award ceiling and expected awards are not specified in the provided source text, so applicants typically need to consult the full FOA and NIH guidance for budget expectations and programmatic constraints.
Overall, this funding opportunity is designed for research teams that can propose a cohesive, multi-project cancer research program with strong scientific integration, credible leadership and coordination via an Administrative Core, and a clear rationale for why a P01 structure is necessary to achieve the goals. It is well-suited to multidisciplinary efforts where progress depends on coordinated basic-to-translational work, shared data or specimens, harmonized methods, or parallel projects that collectively address a major cancer problem from multiple angles.Apply for PAR 20 077
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "National Cancer Institute Program Project Applications (P01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.399.
- This funding opportunity was created on 2020-01-27.
- Applicants must submit their applications by 2023-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental or Substance Use Disorders or Alcohol Disorder (U19 Clinical Trial Optional) Apply for PAR 20 119 Funding Number: PAR 20 119 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Strengthening the Impact of Community Health Workers on the HIV Care Continuum in the US (R01 Clinical Trial Optional) Apply for RFA NR 20 002 Funding Number: RFA NR 20 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
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| Research to Reduce Morbidity and Improve Care for Pediatric, and Adolescent and Young Adult (AYA) Cancer Survivors (R21 Clinical Trial Optional) Apply for RFA CA 20 028 Funding Number: RFA CA 20 028 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
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| Extracellular RNA carrier subclasses in processes relevant to Substance Use Disorders or HIV infection (R01- Clinical Trial Not Allowed) Apply for PAR 20 147 Funding Number: PAR 20 147 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| Addressing Racial Disparities in Maternal Mortality and Morbidity (R01 Clinical Trial Optional) Apply for RFA MD 20 008 Funding Number: RFA MD 20 008 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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