Dual Purpose with Dual Benefit: Research in Biomedicine and Agriculture Using Agriculturally Important Domestic Animal Species (R01) | PAR 23 031

Opportunity Information: Apply for PAR 23 031

The Dual Purpose with Dual Benefit: Research in Biomedicine and Agriculture Using Agriculturally Important Domestic Animal Species (R01) funding opportunity (PAR 23-031) is a National Institutes of Health (NIH) research grant solicitation that supports R01 projects using large, agriculturally important domestic animals as research models in ways that simultaneously advance human health knowledge and improve outcomes relevant to animal agriculture. The central idea is to make better, more intentional use of farm animal species whose biology can closely mirror key aspects of human development, physiology, and disease processes, so that studies are not only scientifically rigorous but also meaningfully translational. The program is positioned to encourage work that yields clear benefits on two fronts: biomedical insight that can inform prevention, diagnosis, or treatment of human disease, and practical gains that can improve animal health and the quality and safety of animal-derived products.

The scientific scope emphasizes carefully designed studies that leverage the unique advantages of domestic species such as cattle, swine, sheep, goats, and other farm animals when they provide a strong match to human systems or when they offer critical agricultural relevance. Priority research areas highlighted in the announcement include normal reproduction and reproductive pathophysiology, normal and abnormal metabolism, and the developmental origins of disease. It also calls out precision nutrition as a major theme, reflecting interest in how targeted nutritional strategies affect growth, metabolic health, reproductive performance, and disease risk across the lifespan. In addition to understanding underlying mechanisms, the FOA explicitly encourages research aimed at improving prevention and treatment of diseases affecting both humans and farm animals, reinforcing the expectation that proposed projects should be designed with dual-purpose outcomes rather than treating the agricultural component as an afterthought.

A key expectation is that each application should address mission-relevant goals of both participating agencies, meaning the proposal should be crafted to deliver value in both biomedical research and agricultural science. In practice, that typically means applicants need to make a compelling case for why the chosen domestic species is the right model for the biomedical question (for example, similarities in organ development, endocrine regulation, immune function, or metabolism) while also explaining how the same work will generate knowledge or tools that matter to animal production, animal health, or product quality. The anticipated outcomes described in the opportunity are twofold: first, generation of fundamental information that can improve human health, and second, measurable progress toward increasing the quality of healthy animal products, which can include improvements tied to animal well-being, productivity, disease resilience, and nutritional or safety characteristics of animal-derived foods.

From an eligibility standpoint, the FOA is broadly open to many U.S.-based applicant types, including state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (when not an institution of higher education); for-profit organizations other than small businesses; small businesses; and other eligible entities. The announcement also explicitly identifies additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions. At the same time, it places clear restrictions on foreign involvement: non-U.S. (foreign) institutions are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components as defined by the NIH Grants Policy Statement are not allowed.

Administratively, this is a discretionary grant opportunity under the NIH grant mechanism, categorized under Health, Income Security and Social Services, with CFDA numbers listed as 93.313, 93.351, and 93.865. The source information indicates an original closing date of 2022-12-15 and a creation date of 2022-10-11. While the provided record does not specify an award ceiling or expected number of awards, the thrust of the opportunity is clear: fund R01-level research projects that thoughtfully use agriculturally important domestic animal species to answer high-priority questions in reproduction, metabolism, developmental biology, and nutrition, producing results that matter to both human medicine and animal agriculture.

• The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Dual Purpose with Dual Benefit: Research in Biomedicine and Agriculture Using Agriculturally Important Domestic Animal Species (R01)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.313, 93.351, 93.865.
• This funding opportunity was created on 2022-10-11.
• Applicants must submit their applications by 2022-12-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

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