Opportunity Information: Apply for PAR 23 031
The Dual Purpose with Dual Benefit: Research in Biomedicine and Agriculture Using Agriculturally Important Domestic Animal Species (R01) funding opportunity (PAR 23-031) is a National Institutes of Health (NIH) research grant solicitation that supports R01 projects using large, agriculturally important domestic animals as research models in ways that simultaneously advance human health knowledge and improve outcomes relevant to animal agriculture. The central idea is to make better, more intentional use of farm animal species whose biology can closely mirror key aspects of human development, physiology, and disease processes, so that studies are not only scientifically rigorous but also meaningfully translational. The program is positioned to encourage work that yields clear benefits on two fronts: biomedical insight that can inform prevention, diagnosis, or treatment of human disease, and practical gains that can improve animal health and the quality and safety of animal-derived products.
The scientific scope emphasizes carefully designed studies that leverage the unique advantages of domestic species such as cattle, swine, sheep, goats, and other farm animals when they provide a strong match to human systems or when they offer critical agricultural relevance. Priority research areas highlighted in the announcement include normal reproduction and reproductive pathophysiology, normal and abnormal metabolism, and the developmental origins of disease. It also calls out precision nutrition as a major theme, reflecting interest in how targeted nutritional strategies affect growth, metabolic health, reproductive performance, and disease risk across the lifespan. In addition to understanding underlying mechanisms, the FOA explicitly encourages research aimed at improving prevention and treatment of diseases affecting both humans and farm animals, reinforcing the expectation that proposed projects should be designed with dual-purpose outcomes rather than treating the agricultural component as an afterthought.
A key expectation is that each application should address mission-relevant goals of both participating agencies, meaning the proposal should be crafted to deliver value in both biomedical research and agricultural science. In practice, that typically means applicants need to make a compelling case for why the chosen domestic species is the right model for the biomedical question (for example, similarities in organ development, endocrine regulation, immune function, or metabolism) while also explaining how the same work will generate knowledge or tools that matter to animal production, animal health, or product quality. The anticipated outcomes described in the opportunity are twofold: first, generation of fundamental information that can improve human health, and second, measurable progress toward increasing the quality of healthy animal products, which can include improvements tied to animal well-being, productivity, disease resilience, and nutritional or safety characteristics of animal-derived foods.
From an eligibility standpoint, the FOA is broadly open to many U.S.-based applicant types, including state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (when not an institution of higher education); for-profit organizations other than small businesses; small businesses; and other eligible entities. The announcement also explicitly identifies additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions. At the same time, it places clear restrictions on foreign involvement: non-U.S. (foreign) institutions are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components as defined by the NIH Grants Policy Statement are not allowed.
Administratively, this is a discretionary grant opportunity under the NIH grant mechanism, categorized under Health, Income Security and Social Services, with CFDA numbers listed as 93.313, 93.351, and 93.865. The source information indicates an original closing date of 2022-12-15 and a creation date of 2022-10-11. While the provided record does not specify an award ceiling or expected number of awards, the thrust of the opportunity is clear: fund R01-level research projects that thoughtfully use agriculturally important domestic animal species to answer high-priority questions in reproduction, metabolism, developmental biology, and nutrition, producing results that matter to both human medicine and animal agriculture.Apply for PAR 23 031
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Dual Purpose with Dual Benefit: Research in Biomedicine and Agriculture Using Agriculturally Important Domestic Animal Species (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.313, 93.351, 93.865.
- This funding opportunity was created on 2022-10-11.
- Applicants must submit their applications by 2022-12-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is the NIH Research Project Grant (R01) solicitation titled "Dual Purpose with Dual Benefit: Research in Biomedicine and Agriculture Using Agriculturally Important Domestic Animal Species (R01)" with funding opportunity number PAR 23-031. It supports R01 research projects that use large, agriculturally important domestic animals as research models in ways that generate both biomedical and agricultural benefits.
What is the central goal of the program?
The central goal is to encourage intentional, rigorous use of farm animal species whose biology can closely mirror key aspects of human development, physiology, and disease. Projects are expected to deliver clear dual-purpose outcomes: (1) biomedical insight relevant to human health and (2) practical gains relevant to animal agriculture, including animal health and the quality and safety of animal-derived products.
What does "dual purpose with dual benefit" mean in practice?
It means the proposed study should be designed from the start to advance human health knowledge while also improving outcomes relevant to animal agriculture. The agricultural component is not expected to be an add-on; the project should be structured so that both biomedical translation and agricultural relevance are integral to the research aims and anticipated outcomes.
What types of animal species are emphasized?
The opportunity emphasizes large, agriculturally important domestic animal species, including cattle, swine, sheep, goats, and other farm animals, when they provide either (a) a strong match to human systems for the biomedical question or (b) critical relevance to animal agriculture (or both).
What are the priority scientific areas highlighted?
Priority areas called out in the announcement include:
- Normal reproduction and reproductive pathophysiology
- Normal and abnormal metabolism
- Developmental origins of disease
- Precision nutrition (as a major theme)
What is meant by "precision nutrition" in this FOA?
Precision nutrition is highlighted as a major theme focused on how targeted nutritional strategies affect growth, metabolic health, reproductive performance, and disease risk across the lifespan. The emphasis is on understanding how nutrition can be tuned to improve outcomes in both biomedical and agricultural contexts.
Does the FOA encourage studies on prevention and treatment of disease?
Yes. The FOA explicitly encourages research aimed at improving prevention and treatment of diseases that affect both humans and farm animals, reinforcing the expectation of dual-purpose outcomes.
How should applicants justify the use of a domestic animal species as a research model?
Applications are expected to make a compelling case that the chosen domestic species is the right model for the biomedical question (for example, due to similarities in organ development, endocrine regulation, immune function, or metabolism) and explain how the same work will generate knowledge or tools that matter to animal production, animal health, or product quality.
What kinds of outcomes is the program looking for?
The anticipated outcomes are twofold:
- Generation of fundamental information that can improve human health (including insight relevant to prevention, diagnosis, or treatment of human disease)
- Measurable progress toward increasing the quality of healthy animal products, which may include improvements related to animal well-being, productivity, disease resilience, and nutritional or safety characteristics of animal-derived foods
What grant mechanism is used?
This is an NIH discretionary grant opportunity using the R01 mechanism (Research Project Grant).
Which agency is offering this opportunity?
The opportunity is a National Institutes of Health (NIH) research grant solicitation. The description also indicates that applications should address mission-relevant goals of participating agencies, meaning the project should be crafted to deliver value in both biomedical research and agricultural science.
Who is eligible to apply?
Eligibility is broadly open to many U.S.-based applicant types, including:
- State, county, and local governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Tribal organizations other than federally recognized tribal governments
- Public housing authorities/Indian housing authorities
- Nonprofit organizations (with or without 501(c)(3) status, when not an institution of higher education)
- For-profit organizations other than small businesses
- Small businesses
- Other eligible entities
Are minority-serving institutions and similar entities eligible?
Yes. The announcement explicitly identifies additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are federal agencies eligible to apply?
Yes. The eligibility list includes eligible federal agencies.
Are faith-based or community-based organizations eligible?
Yes. The eligibility list explicitly includes faith-based or community-based organizations.
Are U.S. territories or possessions eligible?
Yes. The eligibility list includes U.S. territories or possessions.
Are foreign (non-U.S.) institutions eligible to apply?
No. The FOA includes clear restrictions stating that non-U.S. (foreign) institutions are not eligible to apply.
Can a U.S. organization include a non-U.S. component?
No. The announcement states that non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed under NIH policy for this opportunity?
No. Foreign components, as defined by the NIH Grants Policy Statement, are not allowed for this FOA.
What is the program category and what CFDA numbers are listed?
The opportunity is categorized under Health, Income Security and Social Services. The CFDA numbers listed are 93.313, 93.351, and 93.865.
What are the key dates provided in the record?
The source information indicates a creation date of 2022-10-11 and an original closing date of 2022-12-15.
Does the provided record specify the award ceiling or number of awards?
No. The provided record does not specify an award ceiling or the expected number of awards.
What is the main takeaway on what NIH wants to fund through this FOA?
NIH aims to fund R01-level projects that thoughtfully use agriculturally important domestic animal species to address high-priority questions in reproduction, metabolism, developmental biology, and nutrition, producing results that are meaningfully translational for human medicine while also improving outcomes important to animal agriculture.
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